Sue Ion

Dame Sue Ion (pronounced /iːɒn/) DBE, FRS, FREng (née Burrows; 3 February 1955) is a British engineer and an expert advisor on the nuclear power industry.

Born Susan Elizabeth Burrows on 3 February 1955 in Cumbria, she is the daughter of Lawrence James Burrows, a planning officer for British Rail, and Doris Burrows (née Cherry), a secretary.

Ion was educated at Penwortham Girls Grammar School near Preston, Lancashire in the same year as Nancy Rothwell. As a young student, she enjoyed science, which her parents encouraged by letting her do chemistry experiments in the family’s kitchen. At school, Ion, took a leadership role as Head Girl from 1972-1973 and deputy leader of the orchestra. At 16, Ion won a book on atomic energy as a prize for her O-levels in science, which helped inspire her enthusiasm for the topic. “When I was in school,” Ion says, “it was quite different. You were given every encouragement possible to do science subjects if you were interested in them”.

Ion went on to study Materials Science at Imperial College London, gaining a first class Bachelor of Science degree and a PhD in Metallurgy in 1979. She taught in an inner London school while completing her doctorate, and used supplies from the college laboratories in her lessons to help students become enthusiastic about the industry. “Where there is no vision,” she says, “the people perish”.

In 1979, Ion was first hired as a technical officer at British Nuclear Fuels (BNFL). At the time, she and one other woman were the only females working in the chemical engineering department how to make tender beef steak. In 1992, she was promoted to Executive Director of Technology, a position Ion held within the organization until 2006 how to use a meat mallet.

During this time, nuclear or atomic energy was viewed as a valuable source of energy, along with the existing coal industry, and a necessary part of rebuilding post-war Britain. It was, according to Ion, an exciting industry with a vibrant research and development program and great prospects. As she told Jim Al-Khalili in a 2013 interview for BBC4 Radio, “Nothing over time has changed my view of that”.

As technical director of BNFL, Ion held a seat on Tony Blair’s Council for Science and Technology and has been credited with persuading Blair to change Labour’s official government’s policy on nuclear power. Ion’s work, along with David King, took about 10 years of educating government officials to consider the scientific evidence surrounding the issues of nuclear power and renewable energy to inform policy. Ion also helped advise Gordon Brown on long-term energy policies.

In 2004, Ion was among 180 women invited to a “Women’s Theme Day” luncheon at Buckingham Palace in recognition of her contributions to the field of science and technology.

Ion was elected a Fellow of the Royal Academy of Engineering in 1996 and was a vice president from 2002-2008.

In 2006, Ion was appointed visiting professor of Imperial College and admitted to the Fellowship of the college in 2005.

Ion has studied energy supplies for more than 30 years. She spent a lot of time early in her career advising government officials about nuclear reactors and countering the negativity caused by the incidents at Three Mile Island and Chernobyl.

Ion supports the development of smaller, modular versions of nuclear reactors for their economy of size, portability and cost. These smaller reactors would, most likely, be housed on existing nuclear sites licensed for that purpose.

Ion views her biggest challenge is “persuading decades-worth of politicians that nuclear energy is really needed underwater cell phone case.” Her position is that renewable energy sources (particularly wind power), coal and nuclear power will be necessary components of Britain’s energy policy moving forward.

In Ion’s outreach as a spokesperson for the nuclear power industry, she has expressed a belief that more needs to be done to attract women into the field of engineering. She is concerned that some areas of the educational system still view engineering as a subject only for males running belt with water bottle holder. While major institutions may support the idea of females entering the field of science and engineering, Ion notes that grade schools under the current system may not provide the prerequisite coursework early enough in students’ academic careers for them to be successful at university.

Ion supports educational programs that support all students, regardless of gender, to explore science and develop the skills necessary to replace what the Royal Academy of Engineering views as a retiring workforce. In response to a report commissioned by the Nuclear Industry Association (NIA) discussing the UK’s plans for future energy production, she cautions: “There will be an unprecedented demand for new infrastructure to support the changes in the energy industry. There are not enough people going into university to study engineering and provide all the turbine specialists, heavy electrical engineers and construction engineers that will be required”.

She married John Albert Ion in 1980 and lives in Leyland, Lancashire.

Fresno (miniseries)

Fresno is a 1986 American television comedy miniseries that parodied prime time soap operas of the time such as Falcon Crest, Dallas, and Dynasty. Fresno was directed by Jeff Bleckner.The series featured high production values, including lavish haute couture gowns by leading costume designer Bob Mackie, a main cast including Carol Burnett, Teri Garr, Charles Grodin and Dabney Coleman, and supporting cast including Charles Keating, Pat Corley, Louise Latham, Tom Poston and Henry Darrow. It was noted at the time as being the first American satirical TV comedy to be made in the then-popular miniseries format.

Parodying popular prime time soap operas of the era such as Dallas, Dynasty, Falcon Crest and Knots Landing, Fresno chronicles the struggle of matriarch Charlotte Kensington (Burnett) to keep control of her dysfunctional family and defend their declining raisin empire against their arch-rival, the villainous Tyler Cane (Dabney Coleman). In the words of a contemporary network press release:

The primary plot of Fresno concerns the ruthless battle for domination of the Fresno raisin industry between the Kensington family and their neighbour and bitter rival, Tyler Cane, as both parties vie to acquire the crucial water rights that will make or break their business. Subplots include the marital conflict between Charlotte’s scheming son Cane (Charles Grodin) and his bitchy, promiscuous wife Talon (Terri Garr), the travails of Charlotte’s “sensitive” younger son Kevin (Anthony Heald), the legal and marital troubles of Kensington ranch-hand Billy Joe Bobb (Bill Paxton) and his wife, housemaid (and aspiring country singer) Bobbi Jo Bobb (Teresa Ganzel), and the continuing struggles of the Kensingtons’ long-suffering foreman, Juan (Luis Avalos). Connecting these various subplots is the blossoming romance between a mysterious, perpetually-shirtless drifter, Torch (Gregory Harrison), who works to reveal the truth behind the death of Charlotte’s husband 20 years earlier, and Charlotte’s naive ‘adopted’ daughter Tiffany (Valerie Mahaffey), whose quest to find her real parents leads to the gradual exposure of the Byzantine hidden relationships between the main characters.

In an ‘historical’ flashback to 1581, explaining the foundation of Fresno, we see a party of Spanish conquistadores exploring northern California. An excited scout returns with wild grapes from a nearby valley, and after tasting them, the Comandante (Henry Darrow) is delighted, declaring them to be delicious. Two other scouts then arrive with more fruit from another nearby valley, but when the Commandante tastes the new grapes, he immediately spits them out in disgust, angrily shouting, “You call these grapes? They taste like Fresno!”

In present-day Fresno, the raisin-growing empire of the once-wealthy Kensington family has fallen on hard times, and they are locked in a bitter struggle with their arch-rival and former business partner, the villainous Tyler Cane. The Kensingtons are pinning their hopes on a new grape variety they have developed, a breakfast raisin with the bran already inside the fruit. Faithful foreman Juan (Luis Avalos) is charged with getting the prototype raisins to the patent office in Sacramento, but on the way he is ambushed by Tyler Cane’s men, who destroy the shipment. Juan is saved by the sudden appearance of a mysterious, shirtless stranger, Torch. He accompanies Juan back to the Kensington ranch, where he is immediately hired as a ranch-hand. As Charlotte shows Torch around the ranch, she explains how, 20 years earlier, her late husband Yancey fell out with his former friend and partner, Tyler Cane, and then died as the result of a mysterious fall into a raisin dehydrator. Torch begins to investigate the Kensingtons’ affairs, awakening suspicions in Charlotte about the circumstances of Yancey’s mysterious death, and later, his conversation with Charlott’e adopted daughter Tiffany sparks her interest in finding her real parents.

In a bid to save the family business, Cane Kensington strikes a deal with sinister businessman Mr Acme (Jeffery Jones), owner of Acme Toxic Waste. He pays Cane to allow him to secretly dump toxic waste into Duke Lake, a private dam owned by Cane’s neighbour Ethel Duke, which is the main water source for both the Cane and Kensington ranches. Suspecting that their meeting may have been overheard by the family maid, Bobbi Jo Bobb, Cane decides to get her out of the way by sending her to Bakersfield to appear on a radio talent show hosted by country music impresario Tucker Akerjanian (Jerry Van Dyke). However, Cane’s patronage upsets Bobbi Jo’s jealous husband Billy Joe Bobb (Paxton), and their ensuing quarrel has tragic and far-reaching consequences.

Crucial to the fortunes of both Tyler Cane and the Kensingtons are the water rights owned by their common neighbour, Ethel Duke (Louise Latham) wholesale slipper socks. Tyler visits Ethel, offering to buy the water rights for $500,000, but she refuses. Later that day, in Fresno, Charlotte is outmanoeuvred by the scheming Tyler, who takes control of the annual Raisin Festival Masquerade Ball (traditionally hosted by the Kensingtons) and vows to erase the Kensington name from Fresno forever. Talon tries to seduce Billy Joe, but he rebuffs her. That night, as Billy Joe listens to Bobbi Jo on the radio, he becomes enraged when she makes an on-air dedication to Cane. He angrily shoots the radio, but the bullet ricochets off it, accidentally killing his neighbour, Ethel Duke. Billy Joe is arrested and charged with murder, and his case is taken up by glamorous public defender Desiree DeMornay (Melanie Chartoff).

Nature-loving Kevin finds dead fish floating in Duke Lake, and soon discovers a leaking Acme Toxic Waste drum at the bottom of the river. Kevin confronts Mr Acme, who orders his henchmen (J.E. Freeman and Michael Richards) to ensure that Kevin doesn’t leave the plant alive, but their first attempt to kill him fails miserably when they blow up Acme’s nearly identical truck by mistake. Talon visits Torch in his room, and tries unsuccessfully to seduce him. A desperate Juan confronts Charlotte and demands a raise at gunpoint, but his courage fails him, and Charlotte punishes him by cutting his wages in half. Cane makes an anonymous phone call to the police, implicating Kevin in the death of Ethel Duke, and Kevin is also arrested and charged with murder.

Ethel Duke’s sudden death triggers a desperate struggle between Tyler Cane and the Kensingtons to buy the water rights from Ethel’s boorish husband, Earl (Pat Corley). Tyler initially gains the upper hand by agreeing to give Earl $250,000 and (at Earl’s insistence) a new Chevy Impala, but when Cane learns of Tyler’s bid, he makes a counter-offer of $300,000, which Earl accepts. That night, Charlotte goes to Earl’s trailer with the intention of seducing him to seal the deal, but her plan is ruined when she discovers that Tyler has already sent his beautiful young “niece” Candy Cane, who emerges from Earl’s bathroom clad only in a towel.

The next day Charlotte visits Kevin in jail, where she is dismayed to learn that his bail has been set at $250,000. Cane blackmails Mr Acme into paying him an additional $300,000, so that he can buy the water rights. He rushes to the bank to clear the cheque, but Charlotte arrives just after he leaves, and immediately withdraws most of the money. Tiffany meets Torch at a Fresno restaurant and asks for his help in finding her real parents. Back at the jail, Kevin and Billy Joe deduce that Cane is behind the entire conspiracy. Bobbi Jo arrives soon after, but when she learns of Talon’s earlier attempt to seduce her husband, she suspects the worst and rejects him.

Rushing back to Earl’s trailer how to use a meat mallet, Cane tries to stop Tyler from buying the water rights, but when Earl phones the bank to verify Cane’s cheque, he learns that it is worthless, because Charlotte has already withdrawn most of the money to pay Kevin’s bail. All seems lost for the Kensingtons, but at that moment Ethel’s attorney arrives – he explains that Earl cannot sell the water rights that day, because Earl will not legally inherit Ethel’s estate until after the reading of the will at 2pm the following day.

Fresno was created and co-written by Barry Kemp, Mark Ganzel, and Michael Petryni, and was produced for CBS by Mary Tyler-Moore’s MTM Productions. The miniseries was directed by Jeff Bleckner, who had previously directed episodes of some of the shows parodied in Fresno, including Dynasty, Knots Landing, and Falcon Crest.

The miniseries starred Carol Burnett and Dabney Coleman, with Charles Grodin, Terri Garr, Valerie Mahaffey, Bill Paxton, Anthony Heald, Gregory Harrison, Luis Avalos, Jerry Van Dyke, Charles Keating, Pat Corley, and Jeffrey Jones.

The production shot for two days in the city of Fresno, California in July 1986, completing its remaining 53 days in Los Angeles. The music was composed by John Morris, and the Emmy-nominated gowns worn by the female leads were designed by Bob Mackie. It was executive produced by Barry Kemp.

Fresno was screened three times in the USA in 1986. 1987 and 1989. It premiered at 8 pm on Sunday 16 November 1986 with a two-hour series opener, followed by four further one-hour episodes over the next four days. (In Australia the miniseries was shown the following year, where it was screened as two two-hour blocks). The 1989 U.S. re-run had an altered soundtrack, with canned laughter added.

As of 2015, Fresno has not been commercially released on any domestic video format; the MTM library is owned by 21st Century Fox.

Henry Hampden Dutton

Henry Hampden Dutton (13 February 1879 – 15 June 1932), often referred to as Harry Dutton, was a South Australian pastoralist, remembered for in 1908 making the first automobile journey from Adelaide to Port Darwin.

He was born in North Adelaide, the son of Henry Dutton, the “Squire of Anlaby” (1844 – 26 August 1914), and studied at St. Peter’s College, Lancing College, Essex, and Magdalen College, Oxford, where he rowed against Cambridge and graduated MA.

He inherited the pastoral property “Anlaby”, near Kapunda in 1914 from his father best hydration belt. He was a keen motorist and in November 1907 attempted the trip to Darwin with noted cyclist-mechanic Murray Aunger (1878–1953) in a 20–24 h.p. Talbot, but was forced to abandon the car in Tennant Creek. Dutton, Aunger and a third member, Ernest Allchurch (c.1870–1932), left Adelaide on 30 June 1908 in a similar vehicle, and completed the journey on 20 August, having recovered the first Talbot on the way. The car and its steel-studded Michelin tyres were reported as having performed flawlessly. In 1921 he and his wife motored from Oodnadatta to Katherine; she was the first woman to make that trip.

He and T. L how to use a meat mallet. Browne purchased Corona Station in 1910, and sold it to Sidney Kidman in 1917.

Henry Hampden Dutton married Emily Martin, niece of James Martin MHA, MLC, on 29 November 1905; their children were;





Selektiver 5-HT1-Rezeptoragonist


Eletriptan (Handelsname Relpax® ; Hersteller Pfizer) ist ein Arzneistoff aus der Gruppe der Triptane, der zur Akutbehandlung der Migräne eingesetzt wird. Es ist ein Agonist an den Serotonin-Rezeptoren des Subtyps 5-HT1B/1D. Eletriptan wurde 1992 von Pfizer patentiert.

Arzneimittel mit dem Wirkstoff Eletriptan sind zur Akutbehandlung der Kopfschmerzen bei einer Migräne mit oder ohne Aura zugelassen. Für diese Anwendung stehen Filmtabletten mit 20 oder 40 mg Eletriptanhydrochlorid zur Verfügung.

Eletriptan darf nicht bei bekannter Überempfindlichkeit gegen den Wirkstoff angewendet werden. Der Wirkstoff darf nicht bei Patienten mit Herzinfarkt, Verdacht auf ischämischer Herzkrankheit, koronaren Vasospasmen (Prinzmetal-Angina), peripheren Erkrankungen der Blutgefäße, mittelschwer bis schwerem oder unkontrolliertem Bluthochdruck angewendet werden. Bei bekannten schweren Leber- oder Nierenfunktionsstörungen oder bei vorübergehenden ischämischen Attacken in der Krankheitsgeschichte sollte Eletriptan ebenso nicht eingesetzt werden. Eletriptan darf nicht gleichzeitig mit Mutterkornalkaloiden und deren Abkömmlingen (zum Beispiel Ergotamin, Dihydroergotamin) angewendet werden best cheap socks, da eine erhöhte Gefahr von Vasospasmen besteht steel bottle.

Da keine ausreichenden Erfahrungen über die Anwendung von Eletriptan bei Schwangeren bestehen, sollte Eletriptan während der Schwangerschaft nur mit Vorsicht und unter strenger Indikationsstellung angewendet werden. Tierexperimentelle Untersuchungen erbrachten keine Hinweise auf embryotoxische oder teratogene Wirkungen.

Eletriptan tritt prinzipiell in die Muttermilch über, wobei sich etwa 0,02 % der Gesamtdosis bei Verabreichung von 80 mg Wirkstoff in der Muttermilch wiederfinden. Ungeachtet der geringen Menge an Eletriptan in der Muttermilch sollte die Anwendung bei stillenden Müttern nur mit Vorsicht erfolgen. Mögliche Wirkungen auf den Säugling lassen sich durch Unterbrechen des Stillens mit Abpumpen und Verwerfen der Muttermilch für mindestens 24 Stunden nach der Einnahme von Eletriptan minimieren.

Eletriptan ist ein selektiver Serotoninagonist für die Rezeptoren des Subtyps 5-HT1B/1D bottled water glass. Darüber hinaus zeigt Eletriptan eine relevante Affinität zu 5-HT1F-Rezeptoren. Diese Rezeptoren kommen auf zerebralen Blutgefäßen und präsynaptisch auf Neuronen vor und ihre Aktivierung durch Eletriptan führt zu einer Konstriktion der während eines Migräneanfalls dilatierten zerebralen Blutgefäße. Andererseits führt Eletriptan zu einer Verminderung der Ausschüttung von blutgefäßdilatierenden und schmerzauslösenden Entzündungsmediatoren wie Serotonin how to use a meat mallet, Calcitonin Gene-Related Peptide (CGRP) und Substanz P.